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Dapagliflozin with metformin for dyslipidemia.
The results have been intriguing. Although LDL-C levels declined slightly, they remained high at a median of 189 mg/dL, with most patients continuing to have elevated LDL-C levels despite a dramatic lowering of cholesterol by diet and exercise.
The most compelling effect of diet intervention was in those who maintained LDL-C below 130 mg/dL and thus reduced their risk of heart attack or stroke. all of the patients, those who were taking lipid-lowering medications had the greatest reduction in LDL-C:
This small pilot study underscores that lowering cholesterol is an effective way to achieve therapeutic goals for coronary artery disease. And as with other major health problems, such as heart disease, the first therapeutic steps should be cholesterol-lowering medications. In the case of dyslipidemia, medications can prevent LDL-C levels, which, as discussed above, have a strong association with cardiovascular disease risk. If LDL-C levels are low by diet alone, a cholesterol-lowering medication like statin therapy may be prescribed to help maintain these levels.
For those with higher LDL-C levels or other signs of cardiovascular disease, such as abnormal heart rate variation (an indication of cardiovascular disease), it may be prudent to avoid dietary interventions and, instead, to follow cardiovascular disease prevention guidelines.
If your blood lipids are in the healthy range, consider a diet.
References
Zhou Y. et al. The effects on total cholesterol, low-density lipoprotein particle size, and high-density size of a fat-rich diet and dietary cholesterol: a randomized controlled clinical trial in subjects with diabetes mellitus – DASH Collaborative Research Group. Hypertension. 2011; 60:1903–1910.
Perez-Diaz E., de Almeida G., Garcia-Ruiz M. M., Garcia-Sanchez Pharmacy degree online usa B., García-Morales S. L., López-Ruiz C., Rodríguez-Peralta M., et al. Effects of a Mediterranean diet on blood pressure: Results of a multicenter randomized study comparing the effects of modified diabetes mellitus therapy and the Mediterranean diet in individuals with type 2 diabetes mellitus and/or hypertension. Am J Hypertens 2013; 28:1041–1048.
Rohatgi B. J., Chatterjee S., P. C. Srinivasan K., Sharma A. S. A randomized trial of cholesterol-lowering diet in healthy obese adults. JAMA Intern Med. 2012; 174:2184–2189.
Vitacost J. K., Knecht S., van den Brandt PA. Effectiveness and cost of a hypocaloric low carbohydrate diet: Can i buy tranexamic acid over the counter systematic review. The Cochrane Database Syst Rev. 2011; 4(2): CD004038.
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